Education

• Ph.D., Biochemistry, University of Geneva, Genève, Switzerland
• M.Sc., Biology, University of Geneva, Genève, Switzerland
• B.Sc., Biology, University of Geneva, Genève, Switzerland

Research interests

• Female reproductive physiology and infertility
• Ovarian cancer
• Polycystic ovary (PCOs)
• Cell signaling (Wnt signaling)
• Glycobiology

Selected publications

Azimian-Zavareh, V., Hossein, G., Ebrahimi, M., Dehghani-Ghobadi, Z., 2018. Wnt11 alters integrin and cadherin expression by ovarian cancer spheroids and inhibits tumorigenesis and metastasis. Experimental Cell Research 369(1): 90-104. doi: 10.1016/j.yexcr.2018.05.010

Hossein, G., Arabzadeh, S., Salehi-Dulabi, Z., Dehghani-Ghobadi, Z., Heidarian, Y., Talebi-Juybari, M., 2017. Wnt5A regulates the expression of ROR2 tyrosine kinase receptor in ovarian cancer cells. Biochemistry and Cell Biology 95(6): 609-615. doi: 10.1139/bcb-2016-0216

Arabzadeh, S., Hossein, G., Zarnani, A.H., 2016. Wnt5A exerts immunomodulatory activity in the human ovarian cancer cell line SKOV-3. Cell Biology International 40(2): 177-87. doi: 10.1002/cbin.10551.

Hossein, G., Keshavarz, M., Ahmadi, S., Naderi, N., 2013. Synergistic effects of PectaSol-C modified citrus pectin an inhibitor of Galectin-3 and paclitaxel on apoptosis of human SKOV-3 ovarian cancer cells. Asian Pacific Journal of Cancer Prevention 14(12):7561-8.

Nisato, R.E., Hosseini, G., Sirrenberg, C., Butler, G.S., Crabbe, T., Docherty, A.J., Wiesner, M., Murphy, G., Overall, C.M., Goodman, S.L., Pepper, M.S., 2005. Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical. Cancer Research 65(20): 9377-9387.

Princivalle, M., Hasan, S., Hosseini, G., de Agostini, A.I., 2001. Anticoagulant heparan sulfate proteoglycans expression in the rat ovary peaks in preovulatory granulosa cells. Glycobiology 11(3): 183-94.

Taraboletti, G., Sonzogni, L., Vergani, V., Hosseini, G., Ceruti, R., Ghilardi, C., Bastone, A., Toschi, E., Borsotti, P., Scanziani, E., Giavazzi, R., Pepper, M.S., Stetler-Stevenson, W.G., Bani, M.R., 2000. Posttranscriptional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells. Experimental Cell Research 258(2): 384-94.

Hosseini, G., Liu, J., de Agostini, A.I., 1996. Characterization and hormonal modulation of anticoagulant heparan sulfate proteoglycans synthesized by rat ovarian granulosa cells. Journal of Biological Chemistry 271(36): 22090-22099.

Montesano, R., Soriano, J.V., Hosseini, G., Pepper, M.S., Schramek, H., 1999. Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells. Cell Growth and Differentiation 10(5): 317-332.