Dr. Shahrokh Safarian

Place of Birth: Tehran, Iran
Marital Status: Married, 2 children
Office Address: Department of Biology, University of Tehran, Tehran - Iran
Telephone: +9821 - 61113237, 61113381(lab)
Fax: +9821 - 6405141
E-mail: safarian@ibb.ut.ac.ir
Safarian@khayam.ut.ac.ir

 

Appointments:


2002, Assistant Professor
 

Education:

B.Sc.
Biology Department, Faculty of Science, University of Shahid Beheshti, 1990

M.Sc.
Biochemistry Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, 1995
Thesis: Chemical synthesis of p-nitrophenyl N-acetyl-β-D Glucosaminide for monitoring of the activity of N-acetyl-β-D-Glucosaminidase in the urine

Ph.D.
Biochemistry Department, Institute of Biochemistry and Biophysics, University of Tehran, 2002
Thesis: Thermodynamic and structural analysis of bovine pancreatic ribonuclease (RNase A)

 

List of publications (Full papers):



1) Z. Moosavi-Movahedi; S. Safarian; and … "Calorimetric and binding dissections of HSA upon interaction with bilirubin". The protein journal (In Press).

2) S. H. Sadat Hayatshahi, P. Abdolmaleki, S. Safarian, and  K. Khajeh "Non-linear quantitative structure–activity relationship for adenine derivatives as competitive inhibitors of adenosine deaminase", Biochemical and Biophysical Research Communications, 338, 1137–1142 (2005).

3) S. Safarian et al. "A statistical mechanical deconvolution of the differential scanning calorimetric profiles of the thermal denaturation of cyanomethemoglobin", The Protein Journal, 24, 175-181 (2005).

4) A. A. Moosavi-Movahedi, S. Safarian and … “QSAR analysis for adenosine deaminase upon interaction with a series of adenine derivatives as inhibitors”, Nuclesides, Nucleotides and Nucleic acids, 23,1-12, (2004).

5) G. Ataie, S. Safarian, and… "Kinetic and structural analysis of adenosine deaminase upon interaction with acetaminophen" J. Enz. Inhib. Med. Chem. 19, 71-78, (2004).

6) M. gharanfoli, A. A. Moosavi-Movahedi, S. Safarian and … "Calorimetric evidence for conformational transitions of RNase A in the presence of 2',3'-cyclic phosphates" Thermochimica Acta, 411, 37-42, (2004).


7) S. safarian et al. "The structural and functional studies of His119 and His12 in RNase A via chemical modification" J. Prot. Chem. 22(7), 643-654, (2003).

8) A. Mohamadi-Nejad, A.A. Moosavi – Movahedi , S. Safarian, H. Naderimanesh, B. Ranjbar, B. Farzami, H. Mostafavi, M.B. Larijani, G.H.Hakimelahi “The thermal analysis of nonenzymatic glycosylation of human serum albumin: differential scanning calorimetry and circullar dichorism studies” Thermochimica Acta 389, 141-151 (2002)

9) M.R. Dayer, A.A. Moosavi-Movahedi, P. Norouzi, H. Ghourchian and  S. Safarian “Inhibition of human hemoglobin auto-oxidation upon interaction with sodium dodecyl sulfate” J. Biochemistry and Molecular Biology 35(4), 364-370 (2002)
 

10) S. Ghobadi, S. Safarian, A. A. Moosavi–Movahedi and B. Ranjbar “Octyl glucoside induced formation of the molten globule-like state of glutamate dehydrogenase” Journal of Biochemistry (Tokyo), 130,671-677 (2001).

11) S. Safarian, A. A. Moosavi – Movahedi “Kinetic and binding pattern of RNase A upon interaction with RNA” J. Protein Chemistry, 19(5), 335-345 (2000).

 

List of published abstracts:

1) S. Safarian, A.A. Moosavi-Movahedi A.A. Saboury “Distinction of Km for high cooperative and non-cooperative sites of RNase A using Hill plot” Biophysical J. 76(1), 179 (1999).

2) S. Ghobadi, B. Ranjbar, S. Safarian and A.A. Moosavi-Movahedi “Octyl glucoside induced formation on the molten globule state of glutamate” Protein Science, Vol. 8, suppl. 2, 60 (1999).

3) Z. Moosavi-Movahedi, S. Safarian, A. A. Saboury and A. A. Moosavi-Movahedi, “Free energy and the position of dissociated protons for acidic conformational states of cytochrom c by titrimetry” Biophysical J. 78(1), 421 (2000).

4) A. Mahmoudi, K. Nazari, N. Mohammadian, S. Safarian and A. A. Moosavi-Movahedi, “The relationship of function and structural stability of horseradish peroxidase by interaction with Cu2+ and Ni2+ ions” Biophysical J. 78(1), 295 (2000).

5) A. Mohamadinejad, A. A. Moosavi-Movahedi, S. Safarian and B. Farzami "Appearance of human serum albumin domains after non-enzymatic glycosylation" Biophysical J. 80(1), 557 (2000).

6) Z. Moosavi-Movahedi, S. Safarian, M. Zahedi, M. Sadeghi and A. A. Moosavi-Movahedi “Two sets binding analysis of bilirubin and human serum albumin complexes “ Biophysical J. 84(2), 508 (2003).

7) S. Safarian, A. A. Moosavi-Movahedi,"Structural binding analysis of bovine pancreatic ribonuclease using chemical modification" 2nd Int. Conf. on Chemistry & its Applications, College of Science, University of Qatar, p. 384 (2003).

 

 

Research Projects Leader:

"Thermodynamic and structural analysis of native human serum albumin and its histidine modified states in the presence of bilirubin" University of Tehran, (current).

 

POSTGRADUATE TEACHING EXPERIENCE

  Completed Current
MSc students 6 4
PhD students --- ---

 

Research students supervised (M.Sc.)

 1) Miss Naghmeh Rajaei (2006) Kinetic and structural study of carbonic anhydrase via chemical modification.

 2) Miss Mona Saffarzadeh (2005) Structural and functional investigations of bovine carbonic anhydrase II in acetonitrile as an organic solvent.

 3) Miss Darya Habibi (2005) Kinetic and structural studies of bovine carbonic anhydrase II in the presence of PNPA as the substrate.

 4) Mr. Abbas Ali Saberi (2004) Analysis of thermal transitions for biological macromolecules (proteins) using the statistical mechanical theories.

 5) Mr. Mehdi Goodarzi (2004) Comparative sequence analysis of motifs with HTH topology.

 6) Mr. Mohammad Reza Khazaey (2004) Glycated proteins and their effects on microglial cells.

 

 

WORKSHOP PRESENTATIONS:

 

Educational Workshop on Biological Spectroscopy, February 13-17 (2004).

Educational Workshop on Enzyme kinetics, June 25-27 (2005).

 

Address:
 

Office Address: Department of Biology, University of Tehran, Tehran - Iran
Telephone: +9821 - 61113237, 61113381(lab)
Fax: +9821 - 6405141
E-mail: safarian@ibb.ut.ac.ir
Safarian@khayam.ut.ac.ir

 

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