Dr. S. Mahmoud Arab Najafi

Academic degree (position): Ph.D (Assistant Professor)

 

E-mail: najafim@khayam.ut.ac.ir


 

Higher Education and Employment


February, 1984-February, 1988: B.Sc in Microbiology from Department of Biology, Faculty of Sciences, University of Tehran, Tehran-Iran.


February, 1988-November, 1990: M.Sc in Medical Microbiology from School of Medical Sciences, University of Tehran, Tehran, Iran.


January, 1991- January, 1992: Instructor of Microbiology at School of Medicine, Shahid Beheshti University, Tehran- Iran.


February, 1992- April, 1993: Research Associate, National Research Center for Genetic Engineering and Biotechnology, Tehran-Iran.


May, 1993-September, 1996: Ph.D from the Department of Biochemistry, University of Oxford, Oxford, England.


April, 1997-June, 1999: Research Scholar (post-doctorate) at School of Medicine, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.


July, 1999-January, 2001: Assistant Professor of the National Research Center for Genetic Engineering and Biotechnology, Tehran, Iran.


February, 2001-December 2002: Post-Doctoral fellow at the Department of Molecular & Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

 

January 2003-Present: Assistant Professor of Molecular Genetics, Department of Biology, University of Tehran, Tehran-Iran.

 

 

General Research interests:

Regulation of signal transduction pathways involved in the regulation of cell growth and differentiation.
 

Mechanism of transcriptional activation and regulatory function during cell differentiation and development.


Molecular biology of cancer, cell-cell adhesion, and cell proliferation.

 

Research Activities:

I am very interested in studying the relationship between signaling pathways and human cancers. Currently we are looking for the relationship between Wnt-signal transduction and two very common cancers in Iran, gastric and esophageal tumors. We are screening tumor samples for mutations in exon 3 of β-catenin gene that has a critical role in the regulation of Wnt-signaling. I am also interested in anti-tumor activities of natural products. At present four students are working under my supervision who will graduate soon.

 

Teaching Activities:

 

I teach undergraduate and graduate courses about molecular genetics and molecular basis of human cancers.

 

publications:

 

1- Diederich, B., Wilkinson, J. F., Magnin, T., Najafi, S. M. A., Errington, J. & Yudkin, M. D. (1994).

Role of interaction between SpoIIAA and SpoIIAB in regulating cell-specific transcription factor σF of Bacillus subtilis. Genes & Development. 8, 2653-2663.

2- Najafi, S. M. A., Willis, A. C. & Yudkin, M. D. (1995).

Site of phosphorylation of SpoIIAA, the anti-anti-sigma factor for sporulation-specific σF of Bacillus subtilis. Journal of Bacteriology 177, 2912-2913.

3- Najafi, S. M. A., Harris, D. A. & Yudkin, M. D. (1996).

The SpoIIAA protein of Bacillus subtilis has GTP-binding properties. Journal of Bacteriology 178, 6632-6634.

4- Errington, J., Feucht, A., Lewis, P. J., Lord, M., Magnin, T., Najafi, S. M. A., Wilkinson, J. F. & Yudkin, M. D. (1996).

Control of the cell-specificity of σF activity in Bacillus subtilis. Phil Trans Royal Soc. 351, 537-542.

5- Najafi, S. M. A., Harris, D. A. & Yudkin, M. D. (1997).

Properties of the phosphorylation reaction catalysed by SpoIIAB that help to regulate sporulation of Bacillus subtilis. Journal of Bacteriology 179, 5628-5631.

6- Najafi, S. M. A., Li, Zheng., Makino, K., and Hung, M. C. (2003).

The Adenoviral E1A induces p21 WAF1/CIP1 expression in cancer cells. Biochemical and Biophysical Research Communication 305, 1099-1104.
 

 

Presentations at Meetings and Conferences

1- S Mahmoud A Najafi. (Oral presentation): “Role of interaction between SpoIIAA and SpoIIAB in regulating cell-specific transcription factor σF of Bacillus subtilis” (1997). Iranian Society of Science and Technology, New York, USA.


2- S Mahmoud A Najafi. (Oral presentation): “Role of G-proteins in the regulation of Wnt-signal transduction”. First Iranian Conference for Cell and Developmental Biology, University of Tehran. 13-14 September 2003.


3- S Mahmoud A Najafi. (Oral presentation): “Molecular Interaction between Helicobacter pylori and Gastric Tumor”. The 3rd Conference of Helicobacter pylori Group. Institute of health, Tehran University of Medical Sciences. Tehran-Iran. 12 June 2003.


4- S Mahmoud A Najafi. (Oral presentation): “Expression of the mouse Gaq using Baculovirus expression system”. The 3rd National Congress of Biotechnology. The Islamic Republic of Iran. University of Ferdowsi, Mashad-Iran. 9-11 September 2003.


5- S Mahmoud A Najafi. (Oral presentation): “Overproduction of Eukaryotic proteins by using Baculovirus expression system”. Iranian Biological Society Meeting. University of Tehran, Tehran-Iran. 3 July 2003.


6- S Mahmoud A Najafi. (Oral presentation): “The adenoviral E1A induces p21WAF1/CIP1 expression in cancer cells”. The First International Congress of Cancer Genetics. Imam Hospital, Tehran University of Medical Sciences. Tehran-Iran. 13-16 December 2003.


7- Majid Tafrihi & S Mahmoud A Najafi. (poster presentation): “Looking for mutations in exon 3 of β-catenin gene in gastric tumor samples”. The 12th Iranian Biology Conference” Bu Ali Sina University of Hamedan. Hamedan-Iran. 31 August-2 September 2004.


8- Roghie Mohammadzadeh & S Mahmoud A Najafi. (poster presentation): “Looking for mutations in exon 3 of β-catenin gene in esophageal tumor samples”. The 12th Iranian Biology Conference” Bu Ali Sina University of Hamedan. Hamedan-Iran. 31 August-2 September 2004.

 

 

Address:

Contact Address (work): Division of Cell & Molecular Biology, Department of Biology, Faculty of Sciences, University of Tehran, P.O.Box 14155-6455,
Tehran-Iran

Tel: (+98) 21 6112618
Fax: (+98) 21 6405141
E-mail: najafim@khayam.ut.ac.ir
 

 

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